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. 2010 Apr 30;38(16):5396–5408. doi: 10.1093/nar/gkq184

Table 4.

Functional classification for genes bound by CBP or p300

T30 p300 higher than CBP
ID (GO:#) Term Count % P-value Enrichment
0010467 Gene expression 81 38.76 Inline graphic 2.06
0044237 Cellular metabolic process 127 60.77 Inline graphic 1.44
0008152 Metabolic process 135 64.59 Inline graphic 1.38
0044238 Primary metabolic process 126 60.29 Inline graphic 1.42
0043170 Macromolecule metabolic process 111 53.11 Inline graphic 1.44
0006350 Transcription 56 26.79 Inline graphic 1.95
0006139 Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 72 34.45 Inline graphic 1.66
0045449 regulation of transcription 53 25.36 Inline graphic 1.91
0016070 RNA metabolic process 58 27.75 Inline graphic 1.8
0019219 Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 53 25.36 Inline graphic 1.87
0010468 Regulation of gene expression 54 25.84 Inline graphic 1.83
0031323 Regulation of cellular metabolic process 54 25.84 Inline graphic 1.76
0043283 Biopolymer metabolic process 84 40.19 Inline graphic 1.47
0019222 Regulation of metabolic process 55 26.32 Inline graphic 1.73
0006351 Transcription, DNA-dependent 48 22.97 Inline graphic 1.81
0032774 RNA biosynthetic process 48 22.97 Inline graphic 1.81
0006355 regulation of transcription, DNA-dependent 46 22.01 Inline graphic 1.77
0006979 Response to oxidative stress 7 3.35 Inline graphic 6.83
0050794 Regulation of cellular process 67 32.06 Inline graphic 1.42
T30 CBP higher than p300
ID (GO:#) Term Count % P-value Enrichment
0051056 Regulation of small GTPase mediated signal transductio 18 7.06 Inline graphic 5.97
0046578 Regulation of Ras protein signal transduction 13 5.10 Inline graphic 5.36
0007242 Intracellular signaling cascade 38 14.90 Inline graphic 2.06
0009966 Regulation of signal transduction 21 8.24 Inline graphic 2.98
0007154 Cell communication 77 30.20 Inline graphic 1.52
0007165 Signal transduction 71 27.84 Inline graphic 1.54
0007265 Ras protein signal transduction 13 5.10 Inline graphic 4.03
0007264 Sall GTPase mediated signal transduction 18 7.06 Inline graphic 2.94
0007399 Nervous system development 23 9.02 Inline graphic 2.4
0016481 Negative regulation of transcription 13 5.10 Inline graphic 3.52
0045934 Negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 13 5.10 Inline graphic 3.22

Significantly enriched GO categories for genes that show higher binding of CBP or p300 at 30 min after stimulation with TPA and serum (ID: GO-category-number, term: description of the GO category; count: number of significant genes in this GO category; %: percentage of signifiacnt genes in this GO category; P-value: statistical significance of the GO category (P-value from hypergeometric test for over-representation); enrichment: fold enrichment of significant genes compared to the background.