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. 2010 Apr 30;38(16):5419–5431. doi: 10.1093/nar/gkq261

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Published by Oxford University Press 2010.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Loop 1 is conserved in pol λ from different species. (A) Sequence alignment of pol λ loop 1 region from different species. Identical residues are in gray background except for K472, which is in red background. Conserved and non-conserved residues are in green and black background, respectively. Human (Hs) pol λ sequence is aligned with sequences of pol λ from: rhesus monkey, Macaca mulatta (Mcm); cattle, Bos taurus (Bt); horse, Equus caballus (Eqc); dog, Canis lupus familiaris (Clf); rat, Rattus norvegicus (Rn); mouse, Mus musculus (Mum); red jungle fowl, Gallus gallus (Gg); western clawed frog, Xenopus (Silurana) tropicalis (Xst); zebrafish, Danio rerio (Dr); human pol β, pol µ and TdT. (B) The sequence of loop 1 in pol λ (nine residues in green background) is replaced with the corresponding sequence in pol β (four residues in yellow background).