Table 4.
Base substitution specificity of pol λ DL
| Base (n) | Mutation | Mispair | Number of occurrences | Error rate × 10−3 |
|
|---|---|---|---|---|---|
| Pol λ DL | Pol λ wt | ||||
| A (99) | A → G | A•dCMP | 51 | 10.3 | 0.69 |
| A → T | A•dAMP | 36 | 7.2 | 0.49 | |
| A → C | A•dGMP | 26 | 5.2 | 0.59 | |
| T (91) | T → C | T•dGMP | 42 | 9.2 | 1.40 |
| T → G | T•dCMP | 10 | 2.2 | ≤0.10 | |
| T → A | T•dTMP | 5 | 1.0 | ≤0.10 | |
| G (95) | G → A | G•dTMP | 35 | 7.4 | 0.30 |
| G → C | G•dGMP | 15 | 3.2 | 0.40 | |
| G → T | G•dAMP | 7 | 1.5 | ≤0.10 | |
| C (122) | C → T | C•dAMP | 15 | 2.5 | ≤0.08 |
| C → A | C•dTMP | 6 | 1.0 | ≤0.08 | |
| C → G | C•dCMP | 4 | 0.7 | ≤0.08 | |
Rates for wt pol λ wt are from (39).