Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Apr 26;38(16):5507–5517. doi: 10.1093/nar/gkq295

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 6. — dDis3 functional regions identified in this work. (Top) dDis3 cell biological features include one N-terminal region that contributes to subcellular localization. The NLS was previously identified (12). (Bottom) dDis3 biochemical features include an N-terminal endoribonucleolytic active site and N-terminal domains that contribute to enzymatic activity overall. The N-terminus also interacts with core exosome proteins, dRrp47, dRrp6 and dImportin-α3. The dDis3 C-terminus contains a region for dRrp6 and Importin-α3 interactions as well. The exoribonuclease activity was previously identified (13).