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. 2010 Apr 22;38(16):5569–5580. doi: 10.1093/nar/gkq259

Figure 3.

Figure 3.

Comparison of sugar puckering and backbone dihedral angles of residue G10 between DNA (a) and RNA (b) quadruplexes. The deoxyribose sugar of the DNA quadruplex adopts a C2′-endo conformation. A C2′-endo conformation for the RNA at this position would cause the C2′ hydroxyl group to sterically clash with the O3′ oxygen atom. The sugar of the G10 residue within the RNA structure therefore adopts a C3′-endo conformation (b), accompanied by alterations in backbone dihedral angles which preserves the positioning of the guanine base within the quartet.