Table 2.
Imidazopurinone and related DNA adducts of human tumour cells lines with low and high expression of glyoxalase 1
Glyoxalase 1 expression |
||
---|---|---|
Analyte | Low | High |
GdG | 1.01 (0.23–1.65) | 1.69 (1.56–2.71) |
MGdG | 1.10 (0.69–1.83) | 10.43 (4.32–13.47)** |
CEdG | 0.49 (0.43–0.69) | 0.77 (0.19–1.77) |
8-OxodG | 1.08 (0.77–1.58) | 8.10 (6.80–15.50)** |
Low Glo1 expression cell lines were NCI-H460 and A549, and high glyoxalase 1 cell lines were MG63 and NCI-H522.
Data are median (upper–lower quartile); adducts per 106 nt.
**P < 0.01 (Mann–Whitney U-test).