Figure 2.

Diversity of T-cell receptor repertoire. (A) A diverse distribution of CDR3 lengths in most of the Vβ families was observed in the spectratype of patient P (red) compared with a healthy control (black), whereas a partially corrected γc-deficient severe combined immunodeficient patient (blue) displayed an oligoclonal repertoire. (B) Quantitative analysis of Vβ distribution in CD4⁺ and CD8⁺T (C) cells showed some under-presentation in a few Vβ families and over-represented in others, particularly in CD8⁺ T cells. The shaded bars represent the patient's cells. The error bars indicate ± 1 SD.