Table 3. Odds ratios (95% confidence intervals) from multivariable models for colorectal cancer risk in categories of total alcohol intake as assessed by food diaries.

	Alcohol intake (g per day)
	Non-drinkers	>0–<5 g per day	5–<15 g per day	15–<30 g per day	30–<45 g per day	⩾45 g per day	P for trend	P trend for drinkers
Main models a
No. of all participants	761	517	559	414	175	149
Colorectal cancer cases	187	112	116	86	40	38
Age-adjusted modelb	1.15 (0.88–1.51)	1.00	0.93 (0.69–1.26)	0.93 (0.68–1.28)	1.13 (0.74–1.72)	1.29 (0.83–2.01)	0.79	0.31
Multivariable model 1c	1.16 (0.88–1.53)	1.00	0.91 (0.67–1.24)	0.90 (0.65–1.25)	1.02 (0.66–1.58)	1.19 (0.75–1.91)	0.82	0.44
Male	1.53 (0.98–2.41)	1.00	1.06 (0.66–1.69)	1.02 (0.63–1.66)	1.20 (0.68–2.12)	1.24 (0.69–2.22)	0.97	0.21
Female	1.00 (0.70–1.42)	1.00	0.84 (0.56–1.26)	0.87 (0.55–1.37)	0.90 (0.43–1.87)	1.52 (0.56–4.10)	0.72	0.97
Sensitivity analysis d
Multivariable model 1c	1.48 (1.08–2.03)	1.00	0.94 (0.66–1.33)	1.00 (0.69–1.45)	1.21 (0.75–1.96)	1.41 (0.85–2.34)	0.79	0.22
Multivariable model 2e	1.49 (1.08–2.05)	1.00	0.93 (0.65–1.33)	0.98 (0.68–1.43)	1.23 (0.76–1.99)	1.39 (0.83–2.32)	0.82	0.17

^aMain conditional logistic regression models: all participants (579 cases and 1996 controls); P-values for trend were drawn from tests for trend by modelling alcohol intake as a continuous variable in a conditional logistic regression analysis, whereas P-values for trend for drinkers were drawn from tests for trend only from non-zero alcohol drinkers.

^bAge adjusted.

^cAdjusted for age, weight, height, smoking status, social class, intakes of energy, fibre, folate, red meat and processed meat.

^dSensitivity analyses: restricted to individuals with complete covariates information (458 cases and 1734 controls).

^eAdjusted for age, weight, height, physical activity, educational level, smoking status, social class, intakes of energy, fibre, folate, red meat and processed meat.