Table 3. Genes found to correlate in multivariate linear regression analysis.
| Model | R | R 2 | Adj R2 | Std. error | Significance (ANOVA) | |
|---|---|---|---|---|---|---|
| (A) | ||||||
| Cisplatin | 0.949 | 0.901 | 0.836 | 35.226 | P<0.001 | |
| Doxorubicin | 0.797 | 0.636 | 0.524 | 98.669 | P<0.007 | |
| Gemcitabine | 0.766 | 0.586 | 0.524 | 88.312 | P<0.001 | |
| Paclitaxel | 0.848 | 0.720 | 0.646 | 78.669 | P<0.001 | |
| Topotecan | 0.900 | 0.811 | 0.751 | 60.457 | P<0.001 | |
| Treosulfan | 0.994 | 0.989 | 0.977 | 10.769 | P<0.001 | |
| Cisplatin+Gemcitabine | 0.899 | 0.807 | 0.743 | 63.769 | P<0.001 | |
| Treosulfan+Gemcitabine | 0.904 | 0.817 | 0.753 | 33.823 | P<0.001 | |
|
Unstandardized
|
Collinearity statistics
|
|||||
| Gene | B | Std. Error | Standardized β | t Lower bound | B | Std. error |
| (B) | ||||||
| Cisplatin | ||||||
| (Constant) | 489.826 | 22.739 | 21.541 | |||
| Rad51 | −41.140 | 6.003 | −0.801 | −6.853 | 0.482 | 2.077 |
| IGF1R | −61.361 | 11.034 | −0.737 | −5.561 | 0.375 | 2.668 |
| p53 | 19.690 | 8.267 | 0.217 | 2.382 | 0.792 | 1.263 |
| Topo I | 43.796 | 9.300 | 0.522 | 4.709 | 0.534 | 1.872 |
| MRP5 | 17.255 | 5.629 | 0.345 | 3.065 | 0.518 | 1.929 |
| Survivin | −11.745 | 4.880 | −0.286 | −2.407 | 0.466 | 2.145 |
| HSP60 | 42.165 | 9.610 | 0.491 | 4.388 | 0.526 | 1.901 |
| BCRP | −21.628 | 5.093 | −0.632 | −4.247 | 0.297 | 3.368 |
| Mcl-1 | 16.918 | 6.486 | 0.252 | 2.609 | 0.707 | 1.414 |
| Ki67 | 11.667 | 5.487 | 0.259 | 2.126 | 0.442 | 2.264 |
| Doxorubicin | ||||||
| (Constant) | 69.454 | 125.422 | 0.554 | |||
| GST pi | 106.938 | 31.844 | 0.649 | 3.358 | 0.751 | 1.332 |
| MRP4 | 80.498 | 25.470 | 0.585 | 3.161 | 0.817 | 1.225 |
| MRP5 | −36.958 | 13.921 | −0.500 | −2.655 | 0.790 | 1.266 |
| Topo IIa | −14.009 | 16.405 | −0.164 | −0.854 | 0.759 | 1.318 |
| Gemcitabine | ||||||
| (Constant) | 407.883 | 28.640 | 14.242 | |||
| (Constant) | 454.312 | 37.512 | 12.111 | |||
| MCJ | −46.173 | 10.778 | −0.621 | −4.284 | 0.983 | 1.018 |
| XRCC1 | 52.043 | 14.788 | 0.571 | 3.519 | 0.785 | 1.274 |
| XPA | −48.982 | 19.639 | −0.402 | −2.494 | 0.797 | 1.255 |
| Paclitaxel | ||||||
| (Constant) | 343.514 | 37.244 | 9.223 | |||
| Survivin | −42.179 | 8.466 | −0.675 | −4.982 | 0.804 | 1.245 |
| IGF2R | 109.226 | 18.578 | 1.122 | 5.879 | 0.405 | 2.472 |
| Mcl-1 | −70.805 | 17.654 | −0.799 | −4.011 | 0.372 | 2.689 |
| GCLM | 40.381 | 12.968 | 0.490 | 3.114 | 0.596 | 1.677 |
| TAP2 | −36.754 | 15.467 | −0.333 | −2.376 | 0.750 | 1.333 |
| Topotecan | ||||||
| (Constant) | 356.986 | 30.510 | 11.701 | |||
| APAF1 | 75.074 | 11.458 | 0.805 | 6.552 | 0.785 | 1.274 |
| SDHA | −42.701 | 9.085 | −0.578 | −4.700 | 0.783 | 1.277 |
| HER2 | −41.223 | 8.955 | −0.618 | −4.604 | 0.657 | 1.521 |
| MRP4 | 55.124 | 15.928 | 0.510 | 3.461 | 0.546 | 1.831 |
| IGF2R | 36.298 | 15.445 | 0.355 | 2.350 | 0.520 | 1.924 |
| Treosulfan | ||||||
| (Constant) | −46.200 | 22.925 | −2.015 | |||
| MLH1 | 42.868 | 1.922 | 0.893 | 22.304 | 0.646 | 1.549 |
| Bax | 75.608 | 5.919 | 0.927 | 12.774 | 0.197 | 5.083 |
| Bcl2 | −31.437 | 1.650 | −1.244 | −19.054 | 0.243 | 4.115 |
| p21 | −69.282 | 3.493 | −1.218 | −19.837 | 0.275 | 3.641 |
| GST pi | 106.821 | 6.921 | 1.176 | 15.433 | 0.178 | 5.608 |
| Ki67 | −17.337 | 1.649 | −0.509 | −10.511 | 0.441 | 2.266 |
| APC N-term | 56.943 | 5.738 | 0.870 | 9.924 | 0.135 | 7.417 |
| HIF1A | −45.059 | 6.890 | −0.566 | −6.539 | 0.138 | 7.224 |
| p16 | 7.875 | 1.539 | 0.208 | 5.117 | 0.629 | 1.589 |
| Survivin | −7.258 | 1.554 | −0.223 | −4.671 | 0.455 | 2.198 |
| Bid | −15.379 | 4.423 | −0.204 | −3.477 | 0.301 | 3.327 |
| Cisplatin+Gemcitabine | ||||||
| (Constant) | −195.787 | 106.134 | −1.845 | |||
| FPGS | 58.087 | 11.147 | 0.630 | 5.211 | 0.733 | 1.364 |
| IGFBP2 | −27.128 | 11.555 | −0.275 | −2.348 | 0.778 | 1.285 |
| MDR1 | −52.072 | 8.573 | −0.871 | −6.074 | 0.520 | 1.922 |
| 18s | 48.716 | 11.831 | 0.578 | 4.118 | 0.543 | 1.841 |
| XRCC5 | 144.209 | 32.907 | 0.859 | 4.382 | 0.278 | 3.591 |
| HIF1A | −76.886 | 25.948 | −0.555 | −2.963 | 0.305 | 3.281 |
| Treosulfan+gemcitabine | ||||||
| (Constant) | 280.890 | 22.522 | 12.472 | |||
| ATP7B | −25.392 | 4.143 | −0.721 | −6.128 | 0.776 | 1.289 |
| Bad | 27.786 | 8.089 | 0.401 | 3.435 | 0.787 | 1.271 |
| MTII | −55.067 | 10.870 | −0.648 | −5.066 | 0.657 | 1.521 |
| p53 | 34.839 | 8.973 | 0.485 | 3.883 | 0.690 | 1.449 |
| IGF2 | −12.457 | 3.713 | −0.391 | −3.355 | 0.791 | 1.265 |
| GCLM | 11.706 | 4.972 | 0.272 | 2.354 | 0.807 | 1.239 |
Abbreviation: ANOVA=analysis of variance.
(A) With ATP-TCA data for recurrent ovarian cancer: model summaries; (B) using forward selection: coefficients for each gene included in the model by drug or combination tested.