Table 1. Gene pathways enriched in temsirolimus-sensitive and -resistant xenografts as per KEGG classification.

Name	KEGG pathway	Size	NES	P	FDR
Pathways enriched in the sensitive cases (P<0.01)
HSA03010	Ribosome	54	2.41	0.000	0.00
HSA05220	Chronic myeloid leukaemia	76	1.86	0.000	0.04
HSA04520	Adherens junction	79	1.83	0.000	0.03
HSA05214	Glioma	64	1.74	0.000	0.06
HSA05212	Pancreatic cancer	73	1.68	0.000	0.08
HSA05215	Prostate cancer	88	1.58	0.008	0.14
HSA04350	TGF-β signalling pathway	87	1.57	0.000	0.13
HSA05211	Renal cell carcinoma	69	1.52	0.007	0.15
Pathways enriched in the resistant cases (P<0.01)
HSA00590	Arachidonic acid metabolism	52	−1.97	0.000	0.00
HSA00260	Glycine, serine and threonine metabolism	45	−1.97	0.000	0.00
HSA00591	Linoleic acid metabolism	35	−1.85	0.000	0.02
HSA00280	Valine, leucine and isoleucine degradation	43	−1.80	0.000	0.03
HSA03320	PPAR signalling pathway	66	−1.78	0.000	0.03
HSA00910	Nitrogen metabolism	23	−1.77	0.006	0.03
HSA00252	Alanine and aspartate metabolism	32	−1.76	0.000	0.03
HSA00450	Selenoamino acid metabolism	28	−1.75	0.000	0.03
HSA00051	Fructose and mannose metabolism	42	−1.66	0.009	0.07
HSA00710	Carbon fixation	22	−1.62	0.009	0.08
HSA00062	Fatty acid elongation in mitochondria	10	−1.62	0.010	0.08
HSA00970	Aminoacyl-tRNA biosynthesis	37	−1.59	0.006	0.10
HSA00620	Pyruvate metabolism	42	−1.58	0.009	0.10
HSA00562	Inositol phosphate metabolism	50	−1.58	0.003	0.09
HSA00650	Butanoate metabolism	44	−1.54	0.009	0.12
HSA00010	Glycolysis/gluconeogenesis	62	−1.49	0.009	0.16
HSA04020	Calcium signalling pathway	175	−1.47	0.008	0.17
HSA04080	Neuroactive ligand–receptor interaction	251	−1.46	0.003	0.17

Abbreviations: FDR=false discovery rate; KEGG=Kyoto Encyclopedia of Genes and Genomes; NES=normalized enrichment score; P=P-value; TGF=transforming growth factor.