Table 4. Genes differentially expressed between high and low CD8+ TIL tumours that are associated with DSS in a large cohort of 157 advanced-stage serous ovarian carcinomas.
| Gene symbol | Description | T | Parametric P-value lymphoc. | Parametric P-value survival | HR | Fold change high/low CD8+ TIL |
|---|---|---|---|---|---|---|
| ENDOG | Endonuclease G | −3.58818 | 0.000469 | 0.007736 | 0.657 | 1.057368 |
| APOL6 | Apolipoprotein L 6 | −3.51777 | 0.000588 | 0.016474 | 0.784 | 1.061243 |
| LOC144817 | Hypothetical protein loc144817 | −3.4572 | 0.000725 | 0.007082 | 0.751 | 1.054609 |
| TNFRSF11B | Tumour necrosis factor receptor superfamily, member 11b (osteoprotegerin) | −3.2365 | 0.001533 | 0.029561 | 0.778 | 1.076219 |
| CCL5 | Chemokine (c-c motif) ligand 5 | −3.05761 | 0.002678 | 0.008189 | 0.78 | 1.06113 |
| SMARCD3 | SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily d, member 3 | −2.89433 | 0.004415 | 0.012281 | 0.715 | 1.044497 |
| HLA-DQB2 | Major histocompatibility complex, class II, DQ β 1 | −2.62341 | 0.009683 | 0.025419 | 0.718 | 1.036787 |
| P2RY2 | Purinergic receptor P2Y, G-protein coupled, 2 | −2.58765 | 0.010682 | 0.04794 | 0.622 | 1.062139 |
| HTATIP2 | HIV-1 tat interactive protein 2, 30kda | −2.50033 | 0.013646 | 0.023893 | 0.749 | 1.04496 |
| ITGB4 | Integrin, β 4 | −2.4564 | 0.015268 | 0.02019 | 0.788 | 1.042571 |
| BRSK1 | BR serine/threonine kinase 1 | −2.4344 | 0.016188 | 0.001032 | 0.634 | 1.043443 |
| CD74 | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) | −2.39153 | 0.018114 | 0.048429 | 0.798 | 1.0387 |
| IRF1 | Interferon regulatory factor 1 | −2.38234 | 0.018578 | 0.018766 | 0.731 | 1.039269 |
| CARD9 | Caspase recruitment domain family, member 9 | −2.34654 | 0.020354 | 0.012632 | 0.733 | 1.053982 |
| GBP5 | Guanylate binding protein 5 | −2.29852 | 0.023022 | 0.026438 | 0.789 | 1.053155 |
| OR4K1 | Olfactory receptor, family 4, subfamily k, member 1 | −2.25082 | 0.025956 | 0.027515 | 0.535 | 1.043061 |
| IDH3A | Isocitrate dehydrogenase 3 (nad+) α | −2.19777 | 0.029762 | 0.004543 | 0.539 | 1.042238 |
| RARRES3 | Retinoic acid receptor responder (tazarotene induced) 3 | −2.17032 | 0.031671 | 0.027127 | 1.26 | 1.039329 |
| GUCY2F | Guanylate cyclase 2f, retinal | −2.09159 | 0.038394 | 0.030464 | 0.683 | 1.064628 |
| C1orf151 | Chromosome 1 open reading frame 151 | −2.08091 | 0.039363 | 0.000145 | 0.582 | 1.037702 |
| PUM2 | Pumilio homologue 2 (drosophila) | −2.04334 | 0.042905 | 0.037206 | 1.617 | 1.026572 |
| SUSD3 | Sushi domain containing 3 | −2.04205 | 0.043025 | 0.0087 | 0.791 | 1.041484 |
| GRM3 | Glutamate receptor, metabotropic 3 | −2.02279 | 0.045086 | 0.007333 | 0.602 | 1.037417 |
| RP9 | Retinitis pigmentosa 9 (autosomal dominant) | 1.979686 | 0.049732 | 0.02947 | 0.506 | 0.970948 |
| TPM2 | Tropomyosin 2 (β) | 2.01335 | 0.046075 | 0.002014 | 1.459 | 0.968061 |
| CREB3L4 | cAMP responsive element binding protein 3-like 4 | 2.024371 | 0.044851 | 0.024523 | 1.448 | 0.969375 |
| ADFP | Adipose differentiation-related protein | 2.028392 | 0.044437 | 0.004516 | 1.279 | 0.954856 |
| ZIC1 | Zic family member 1 (odd-paired homologue, drosophila) | 2.034892 | 0.043757 | 0.024456 | 1.214 | 0.941812 |
| TCF4 | Transcription factor 4 | 2.038027 | 0.043448 | 0.041311 | 1.317 | 0.965471 |
| RKHD1 | Ring finger and KH domain containing 1 | 2.054802 | 0.041812 | 0.026765 | 0.6 | 0.971522 |
| AKAP12 | A kinase (PRKA) anchor protein (gravin) 12 | 2.05607 | 0.041754 | 0.020387 | 1.448 | 0.965955 |
| CENPF | Centromere protein f, 350/400 ka (mitosin) | 2.079257 | 0.039457 | 0.017257 | 1.28 | 0.955777 |
| TF | Transferrin | 2.085059 | 0.039044 | 0.019715 | 1.302 | 0.95165 |
| MARCKS | Myristoylated alanine-rich protein kinase c substrate | 2.085433 | 0.038849 | 0.01913 | 1.361 | 0.967259 |
| FBN3 | Fibrillin 3 | 2.08694 | 0.038733 | 0.008793 | 1.266 | 0.942574 |
| TSPAN13 | Tetraspanin 13 | 2.102597 | 0.037447 | 0.00351 | 1.465 | 0.962836 |
| C1orf85 | Chromosome 1 open reading frame 85 | 2.149681 | 0.033301 | 0.009093 | 1.684 | 0.969927 |
| NT5C2 | 5′-nucleotidase, cytosolic II | 2.151955 | 0.033136 | 0.042652 | 0.735 | 0.959484 |
| DAD1 | Defender against cell death 1 | 2.163076 | 0.032559 | 0.039308 | 1.509 | 0.971288 |
| COL11A1 | Collagen, type xi, α 1 | 2.180716 | 0.03094 | 0.008437 | 1.149 | 0.926402 |
| GLT25D1 | Glycosyltransferase 25 domain containing 1 | 2.183846 | 0.030707 | 0.011982 | 1.464 | 0.966298 |
| GMFB | Glia maturation factor, β | 2.381146 | 0.018725 | 0.011898 | 1.432 | 0.962138 |
| SNRPE | Small nuclear ribonucleoprotein polypeptide e | 2.38174 | 0.018656 | 0.012262 | 1.462 | 0.983812 |
| ZNF281 | Zinc-finger protein 281 | 2.473985 | 0.014571 | 0.023546 | 1.587 | 0.957854 |
| FABP4 | Fatty acid binding protein 4, adipocyte | 2.485825 | 0.014192 | 0.025061 | 1.11 | 0.908835 |
| SAE2 | SUMO1 activating enzyme subunit 2 | 2.489129 | 0.014051 | 0.018709 | 1.535 | 0.965225 |
| BASP1 | Brain abundant, membrane attached signal protein 1 | 2.533806 | 0.012459 | 0.032678 | 1.235 | 0.94384 |
| ARMCX3 | Armadillo repeat containing, x-linked 3 | 2.563703 | 0.011458 | 0.006661 | 1.562 | 0.94847 |
| CPVL | Carboxypeptidase, vitellogenic-like | 2.690174 | 0.008038 | 0.048239 | 1.295 | 0.957396 |
| FMOD | Fibromodulin | 2.76574 | 0.006462 | 0.012624 | 1.289 | 0.945678 |
| C3orf59 | Chromosome 3 open reading frame 59 | 2.822682 | 0.005501 | 0.022204 | 1.433 | 0.950026 |
| PXDN | Peroxidasin homologue (drosophila) | 2.920898 | 0.004082 | 0.049685 | 0.746 | 0.94662 |
| MEST | Mesoderm specific transcript homologue (mouse) | 3.590373 | 0.000463 | 0.002053 | 1.328 | 0.940516 |
| HMGA2 | High mobility group at-hook 2 | 3.770553 | 0.00024 | 0.031783 | 1.128 | 0.886346 |
Abbreviations: DSS=disease-specific survival; TIL=tumour-infiltrating lymphocyte; HR=hazard ratio.