Table 3.

Direct, Indirect, and Total Effects of Fat Mass and Obesity-Associated (FTO) Genotype rs9939609 on Body Mass Index During the Life Course in the Northern Finland Birth Cohort 1966, 1965–1997

Model	β (×10−3)	Standard Error (×10−3)	Standardized β	P Value	Change, ‰	95% CI	Corresponding Change in Mean BMI, g/m2	95% CI
Maternal BMIa
Total effect	6.00	2.73	0.031	0.03	6.18	0.64, 12.0	143	14.9, 279
BMI at birth
Total effect	3.24	1.94	0.023	0.09	3.30	−0.56, 7.30	45.5	−7.71, 101
Total indirect effect	0.68	0.32	0.005	0.03	0.68	0.06, 1.31	9.42	0.84, 18.1
1) FTO–maternal BMI–birth BMI	0.68	0.32	0.005	0.03	0.68	0.06, 1.31	9.42	0.84, 18.1
Direct effect	2.56	1.91	0.018	0.18	2.60	−1.18, 6.52	35.8	−16.3, 90.0
BMI at age 14 years
Total effect	6.19	2.95	0.033	0.04	6.39	0.41, 12.7	124	7.88, 23.5
Total indirect effect	1.36	0.55	0.007	0.01	1.37	0.28, 2.47	26.6	5.52, 47.8
1) FTO–maternal BMI–BMI at 14	1.02	0.48	0.005	0.03	1.02	0.08, 1.97	19.8	1.55, 38.3
2) FTO–birth BMI–BMI at 14	0.27	0.21	0.001	0.19	0.27	−0.14, 0.68	5.28	−2.67, 13.3
3) FTO–maternal BMI–birth BMI–BMI at 14	0.07	0.04	0.000	0.05	0.07	0.00, 0.14	1.40	−0.01, 2.81
Direct effect	4.83	2.88	0.026	0.09	4.95	−0.82, 11.1	92.1	−15.8, 214
BMI at age 31 years
Total effect	14.0	3.45	0.060	5.0 × 10−5	15.0	7.50, 23.1	371	185, 570
Total indirect effect	4.78	2.04	0.021	0.02	4.90	0.79, 9.17	121	19.6, 227
1) FTO–maternal BMI–BMI at 31	0.69	0.33	0.003	0.04	0.69	0.04, 1.34	17.0	1.02, 33.1
2) FTO–BMI at 14–BMI at 31	3.20	1.90	0.014	0.09	3.25	−0.53, 7.17	80.2	−13.0, 177
3) FTO–maternal BMI–BMI at 14–BMI at 31	0.67	0.32	0.003	0.03	0.67	0.05, 1.30	16.7	1.20, 32.2
4) FTO–birth BMI–BMI at 14–BMI at 31	0.18	0.14	0.001	0.19	0.18	−0.09, 0.45	4.45	−2.28, 11.2
5) FTO–maternal BMI–birth BMI–BMI at 14–BMI at 31	0.05	0.02	0.000	0.05	0.05	0.00, 0.10	1.19	0.02, 2.35
Direct effect	9.22	2.88	0.040	0.001	9.66	3.63, 16.0	239	89.6, 396

Abbreviations: BMI, body mass index; CI, confidence interval; FTO, fat mass and obesity-associated.

^aWeight (kg)/height (m)².