Table 2.

Efficacy of milnacipran compared with SSRIs: comparison of two studies in mild-to-moderate and severe depression

	Mean MADRS scores
	Mild-moderate32		Severe33
	Miln	SSRI1	Miln	SSRI2
Baseline	28.9	29.6	37.1	35.5
Endpoint	13.6§	12.8§	12.9§,*	18.1§
Δ score (endpoint – baseline)	15.3	16.8	24.2*	17.4

¹Notes: paroxetine 20 mg/day;

²fluvoxamine 200 mg/day;

^§P < 0.05 compared with the corresponding baseline value;

^*P < 0.05 compared with the corresponding value for the SSRI group.

Abbreviations: MADRS, montgomery asberg depression rating scale; miln, milnacipran 100 mg/day; SSRIs, selective serotonin reuptake inhibitors.