Table 5.

Adverse effects of paliperidone compared to other antipsychotics

Drug	QTc prolongation	Hypotension	Sedation	Weight gain	Metabolic syndrome	Extrapyramidal symptoms	Anticholinergic	Prolactin elevation
Amisulpride	+	−	−	−	+	+	−	+++
Aripiprazole	−	−	−	+/−	+/−	+/−	−	−
Asenapine	+	−	+	−	−	+	−	+/−
Chlorpromazine	++	+++	+++	++	++	++	++	+++
Clozapine	+	+++	+++	+++	+++	−	+++	−
Haloperidol	+++	+	+	+	+	+++	+	+++
Olanzapine	+	+	++	+++	+++	+/−	+	+
Paliperidone	−/+	++	+	++	++	+	+	+++
Quetiapine	++	++	++	++	++	−	+	−
Risperidone	+	++	+	++	++	+	+	+++
Sulpiride	+	−	−	+	+	+	−	+++

Abbreviations: +++, high incidence/severity; ++, moderate incidence/severity; +, low incidence/severity; −, very low incidence/severity. Adapted from The Maudsley Prescribing Guidelines 10th Edition.³⁰