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. 2010 Sep 13;5(9):e12724. doi: 10.1371/journal.pone.0012724

Figure 1. Flow chart showing the guidelines for HPV E6/E7 mRNA testing.

Figure 1

Women with ASC-US or LSIL at triage and with a positive HPV result are referred to colposcopy and biopsy; if the HPV test is negative, the woman is referred to a third Pap-smear after one year. Women with normal cytology and a positive HPV mRNA result at triage are recommended to have a third Pap-smear and a new HPV mRNA test after 6 months; women with a persistent HPV mRNA result are referred to colposcopy and biopsy. Women with ASC-H and HSIL at triage are referred directly to histological investigation regardless of HPV status.