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. 2010 Sep 13;5(9):e12498. doi: 10.1371/journal.pone.0012498

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Delaney et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Data represents the paw withdrawal latency [A], paw withdrawal threshold [B] as measures of thermal hyperalgesia and mechanical allodynia prior to and post-injection of CFA (n = 4–5 per genotype), shown as mean responses ± SEM. Differences in behaviours prior to injection were observed in female Mc1r^e mice only, when compared to their control littermates, Tg-Mc1r^e in [A] paw withdrawal latency (††P<0.01). CFA-induced increased ipsilateral sensitivity (IPSI; injured hindlimb) compared to contralateral (CON; un-injured hindlimb) are shown (*P<0.05). Female Mc1r^e mice were found to have a significantly higher ipsilateral thresholds when compared to their control littermates, Tg-Mc1r^e ipsilateral thresholds in [A] paw withdrawal latency and [B] paw withdrawal threshold at 0.5–2 hours post-injection (¶P<0.05).