Figure 4. Behavioural analysis of CCI-induced thermal hyperalgesia and mechanical allodynia.

Data represent the paw withdrawal latency [A], paw withdrawal threshold [B] as measures of thermal hyperalgesia and mechanical allodynia respectively in male and female Mc1r^e, Tg-Mc1r^e, A^y-Jkn1 and control non-A^y-Jkn1 adult mice, prior to- and post-surgery shown as the area under the curve (AUC; which measures the total change over the time course (baseline to post-surgery day 21) of CCI-induced thermal hyperalgesia and mechanical allodynia; n = 5–6 per genotype). AUC's were calculated from raw data by the standard trapezoidal rule. No significant differences in either male or female mice were observed.