Figure 5. Concentration-dependent aversion to capsaicin consumption.

Concentration related aversion to capsaicin in adult [A] male and [B] female Mc1r^e and their control littermates Tg-Mc1r^e (n = 6–7 per genotype). Data is expressed as an aversion index ranging from −1 to 1, which measures the degree to which the solution was avoided during the 10 day exposure at each capsaicin concentration tested ± SEM and was calculated by subtracting capsaicin consumed from water consumed, differences in Mc1r^e consumption of capsaicin are shown (**P<0.01) compared to control Tg-Mc1r^e group. [C] Shows the concentration threshold for capsaicin (at 0.83 µM) in the first trial of male and female mice, followed by a repeat trial in naïve animals (not previously assessed for oral aversion) data is expressed as the volume capsaicin containing solution consumed as a percentage of body weight ± SEM during the 10 day exposure, differences in Mc1r^e consumption of capsaicin at 0.83 µM are shown (††P<0.01) compared to control Tg-Mc1r^e group.