Table 1. Summary of Results.

	MALE		FEMALE
	Mc1re compared to Tg-Mc1re	Ay-Jkn1 compared to control non-Ay-Jkn1	Mc1re compared to Tg-Mc1re	Ay-Jkn1 compared to control non-Ay-Jkn1
Acute test (naïve animals)
Noxious heat	no difference	no difference	increased threshhold	no difference
Mechanical	no difference	no difference	no difference	no difference
Formalin response (tonic inflammation)
Response	no difference	no difference	decreased response	decreased response
CFA (model of persistent inflammation)
Noxious heat	no difference	no difference	delayed sensitivity	no difference
Mechanical	no difference	no difference	delayed sensitivity	no difference
CCI (model of peripheral neuropathy)
Noxious heat	no difference	no difference	no difference	no difference
Mechanical	no difference	no difference	no difference	no difference
Capsaicin oral aversion (activation of noxious heat receptor)
Aversion	no difference	not tested	reduced aversion	not tested

Results are summarized for adult male and female mice comparing; Mc1r^e , recessive yellow mice with their littermate controls Tg- Mc1r^e and A^y-Jkn1, agouti signalling protein over-expressing mice with their littermate controls, control non- A^y-Jkn1. All mice were tested for behavioural responses to acute (noxious thermal or mechanical stimuli) tests, formalin response, CFA and CCI-induced thermal hyperalgesia and mechanical allodynia, oral aversion was tested in Mc1r^e and Tg-Mc1r^e mice only.