Table 1.

Primate Injection Conditions

Study name	Age (years)	Weight (kg)	Limb	Inj. vol. (ml)	Inj. vol./ limb vol.	Tourniquet pressure (mmHg)	pDNA dose (mg)	Health problemsa
Papaverine study	34	11.5	Arm	84	0.35	700	5	None
			Leg	133	0.35		5	None
			Arm	84	0.35		5	None
			Leg	133	0.35		5	None
Tourniquet pressure study	22	11.0	Arm	105	0.35	475	10	None
			Leg	130	0.30	700	10	None
			Arm	105	0.35	700	10	None
			Leg	130	0.30	475	10	None
Tourniquet pressure study	6	9.2	Arm	124	0.35	700	10	None
			Leg	142	0.35	475	10	None
			Arm	124	0.35	700	10	None
			Leg	142	0.35	475	10	None
Injection rate study (0.5 ml/sec)	2.5	4.0	Arm	63	0.45	450	11	None
			Leg	90	0.45		16	None
			Arm	63	0.45		11	None
			Leg	90	0.45		16	None
Injection rate study (4.0 ml/sec)	2.5	4.6	Arm	74	0.45	450	13	None
			Leg	112	0.45		20	None
			Arm	74	0.45		13	None
			Leg	112	0.45		20	None
Tourniquet time study	3	4.2	Arm	55	0.45	450	10	None
			Leg	86	0.45		15	None
			Arm	55	0.45		10	None
			Leg	86	0.45		15	None
Tourniquet time study	20	8.3	Arm	125	0.45	450	22	None
			Leg	180	0.45		32	None
			Arm	125	0.45		22	None
			Leg	180	0.45		32	None
Exsanguination study	20	6.5	Arm	113	0.45	450	21	None
			Leg	130	0.45		24	None
			Arm	117	0.45		21	None
Laser Doppler studies	3.5	6.5	Arm	85	0.45	450	None	None
	3	4.0	Arm	56	0.45		None	None
	2	3.3	Arm	45	0.40		None	None
NCS-EMG studies	5	7.2	Arm	96	0.40	450	None	None
	4	6.5	Arm	72	0.40		None	None
FMS studies	4	6.5	Arm	90	0.45	450	None	None
	4	7.0	Arm	90	0.45		None	None
	5.5	7.0	Arm	99	0.45		None	None
	5.5	8.5	Arm	120	0.45		None	None

Abbreviations: FMS, fine motor skill; Inj. vol., injection volume; NCS-EMG, nerve conduction study-electromyography; pDNA, plasmid DNA.

^aPost procedure health problems were defined as changes in overall activity, changes in the use of the injected limb, and any unresolved limb swelling or bruising.