Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Aug 10;5(8):e12097. doi: 10.1371/journal.pone.0012097

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Jamali et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

The mechanical properties of the cytoskeleton are modeled using Voigt subunits; the spring constants of the model are linear approximations to the elasticity of the inner cell. All springs can be considered subject to a damping force due to the viscosity of the cytoplasm, where linear dash-pots are used to approximate the viscosity of the cytoskeleton. In our model, the cytoskeleton is divided into uniformly radial distributed parts, each of which is replaced by a Voigt subunit radiating from the nucleus (blue subunits). Each subunit connects two points of the cell and nuclear membrane, which are located at a radial direction from the center of the nucleus. The model also contains Voigt subunits in the nucleus (red subunits), each of which connect two nuclear membrane points and in which equal to , This allows the nucleus to show more resistance to changes in its shape and volume due to exterior pressure. is the cytoskeletal force acting on and is calculated by Eq. (3). is the force acting on from the cytoskeleton and nuclear cytoskeleton and is calculated by Eq. (4).

Inline graphic — The mechanical properties of the cytoskeleton are modeled using Voigt subunits; the spring constants of the model are linear approximations to the elasticity of the inner cell. All springs can be considered subject to a damping force due to the viscosity of the cytoplasm, where linear dash-pots are used to approximate the viscosity of the cytoskeleton. In our model, the cytoskeleton is divided into uniformly radial distributed parts, each of which is replaced by a Voigt subunit radiating from the nucleus (blue subunits). Each subunit connects two points of the cell and nuclear membrane, which are located at a radial direction from the center of the nucleus. The model also contains Voigt subunits in the nucleus (red subunits), each of which connect two nuclear membrane points and in which equal to , This allows the nucleus to show more resistance to changes in its shape and volume due to exterior pressure. is the cytoskeletal force acting on and is calculated by Eq. (3). is the force acting on from the cytoskeleton and nuclear cytoskeleton and is calculated by Eq. (4).