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. 2010 Aug 10;5(8):e12097. doi: 10.1371/journal.pone.0012097

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Jamali et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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In 3D culture, our model allows for the investigation of a cross section of the system and the cells that are immersed in ECM. In 2D, the contact region of the ECM and the cell is a line that surrounds the cell; therefore, an enclosed curve (or ring) can be used for the ECM that surrounds the cells (blue curve). The ECM is modeled using a chain of subunits connected in series, where each point connects two subunits (blue curve with red points). These subunits can interact with cell points in a manner similar to the interaction of two points of different cells. This chain is flexible and the number of its corresponding points can be increased or decreased.