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. 2010 Sep 15;21(18):3205–3219. doi: 10.1091/mbc.E09-06-0452

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© 2010 by The American Society for Cell Biology

This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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Figure 12. — Overexpression of Mcm10 and Cdc17 may hinder polymerase switching. After pol-α extends the RNA primer (red line) by 12–20 nucleotides, Mcm10 is ubiquitinated at two distinct lysines (yellow star; (Das-Bradoo et al., 2006). PCNA is recruited to the lagging strand, and a polymerase switch occurs between pol-α and pol-δ, after which pol-α is released from ubiquitinated Mcm10 and recognized by Ubc4 and Not4. The question mark denotes the fact that it is currently unclear whether the interaction is direct or indirect. Accumulation of Cdc17 and Mcm10 interferes with the switch to pol-δ, allowing pol-α to synthesize more DNA than in wild-type cells.