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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2010 Sep;19(9):2143–2151. doi: 10.1158/1055-9965.EPI-10-0374

Figure 1.

Figure 1

ORs and Ptrends were calculated coding individuals who were common homozygotes for all genotyped SNPs as 0, individuals who were heterozygous for any rare variant as 1 and individuals who were rare homozygotes as 2 (statistical methods). Horizontal lines represent 95% CIs. The diamond represents the combined, fixedeffects estimate of the OR and 95% CI. The vertical line indicates the null effect (OR = 1.0).

Trend OR estimates for S49C, S707P, F858L, P1054R and L1420F combined by study in (a) all cases and all controls and (b) bilateral cases and cases with a family history of breast cancer and all controls