Figure 4.

TLR4 deficiency does not reduce macrophage accumulation after UUO. (Top) Quantitative analysis of interstitial macrophages in obstructed and contralateral kidneys of WT (□) and TLR4−/− (■) mice after UUO. In WT and TLR4−/− mice, an increase of interstitial macrophages is observed in the obstructed kidneys, peaking at 14 days after UUO. The amount of macrophages is higher in the TLR4−/− mice 3 days after UUO when compared with WT mice. (Bottom) Representative pictures of WT and TLR4−/− mice are of 14 days after UUO. Data are means ± SEM of seven to eight mice per group. Contral., contralateral kidneys of mice subjected to 14 days of UUO. *P < 0.05. Magnification, ×200.