Table 3.
IRRs for CVD death, total mortality, CVD composite events, and ESRD for the AASK
| Patient Subgroup | ESRD/CVD Death |
ESRD/CVD Composite |
ESRD/All Death |
||||||
|---|---|---|---|---|---|---|---|---|---|
| IRR (95% CI) | P | Interaction P | IRR (95% CI) | P | Interaction P | IRR (95% CI) | P | Interaction P | |
| All patients | 5.01 (3.77 to 6.66) | <0.001 | 1.21 (1.02 to 1.43) | 0.025 | 1.80 (1.48 to 2.17) | <0.001 | |||
| Age (years) | |||||||||
| ≤55 | 8.76 (5.66 to 13.55) | <0.001 | <0.001 | 1.89 (1.49 to 2.38) | <0.001 | <0.001 | 3.98 (2.92 to 5.42) | <0.001 | <0.001 |
| >55 | 2.78 (1.90 to 4.07) | <0.001 | 0.72 (0.57 to 0.92) | 0.009 | 0.89 (0.68 to 1.16) | 0.38 | |||
| Baseline UP/Cr | |||||||||
| ≤0.22 | 2.35 (1.65 to 3.34) | <0.001 | <0.001 | 0.60 (0.47 to 0.76) | <0.001 | <0.001 | 0.89 (0.69 to 1.14) | 0.35 | <0.001 |
| >0.22 | 12.18 (7.13 to 20.8) | <0.001 | 2.62 (2.01 to 3.41) | <0.001 | 3.92 (2.89 to 5.32) | <0.001 | |||
| Education | |||||||||
| high school or higher | 6.48 (4.35 to 9.63) | <0.001 | 0.03 | 1.59 (1.26 to 2.00) | <0.001 | <0.001 | 2.37 (1.84 to 3.06) | <0.001 | <0.001 |
| lower than high school | 3.49 (2.28 to 5.34) | <0.001 | 0.82 (0.63 to 1.06) | 0.13 | 1.24 (0.93 to 1.64) | 0.14 | |||
| Gender | |||||||||
| female | 4.37 (3.08 to 6.19) | <0.001 | 0.24 | 1.41 (1.08 to 1.84) | 0.01 | 0.14 | 2.60 (1.87 to 3.61) | <0.001 | 0.005 |
| male | 6.26 (3.90 to 10.05) | <0.001 | 1.09 (0.89 to 1.34) | 0.40 | 1.46 (1.17 to 1.84) | 0.001 | |||
| Income | |||||||||
| <$15,000 | 4.86 (3.26 to 7.26) | <0.001 | 0.58 | 1.07 (0.86 to 1.35) | 0.54 | 0.20 | 1.75 (1.33 to 2.30) | <0.001 | 0.66 |
| ≥$15,000 | 5.86 (3.44 to 10.00) | <0.001 | Reference | 1.38 (1.02 to 1.86) | 0.04 | Reference | 1.91 (1.39 to 2.62) | <0.001 | Reference |
| declined to answer | 4.21 (2.20 to 8.08) | <0.001 | 0.18 | 1.32 (0.89 to 1.96) | 0.16 | 0.87 | 1.74 (1.11 to 2.71) | 0.02 | 0.512 |
| Mean baseline GFR | |||||||||
| >40 | 2.39 (1.66 to 3.45) | <0.001 | 0.43 | 0.56 (0.44 to 0.71) | <0.001 | <0.001 | 0.95 (0.73 to 1.23) | 0.68 | <0.001 |
| ≤40 | 11.05 (6.70 to 18.20) | <0.001 | 2.89 (2.22 to 3.76) | <0.001 | 3.26 (2.49 to 4.28) | <0.001 | |||
| Preexisting CVD | |||||||||
| yes | 3.33 (2.37 to 4.67) | <0.001 | <0.001 | 0.95 (0.76 to 1.17) | 0.61 | <0.001 | 1.40 (1.09 to 1.80) | 0.009 | <0.001 |
| no | 8.83 (5.33 to 14.64) | <0.001 | 1.58 (1.24 to 2.02) | 0.0002 | 2.38 (1.79 to 3.16) | <0.001 | |||
Shown are unadjusted IRRs. Follow-up for CVD events and mortality was terminated at occurrence of ESRD. The interaction P value tested whether IRRs differed between the indicated subgroups.