Table 2.

Area under the ROC curve and 95% CIs for the prediction of the composite of doubling of serum creatinine or end-stage renal disease based on baseline proteinuria measures

	Subjects/Events	Doubling of Serum Creatinine or End-Stage Renal Disease
		24-Hour Urine		First-Morning Void
		UAE (mg/24 h)	UPE (mg/24 h)	UAC (mg/L)	ACR (mg/g)
Overall	701/202	0.78 [0.74, 0.82]	0.78 [0.75, 0.82]	0.79 [0.75 to 0.83]	0.82 [0.79, 0.86]a,b,c
Subgroups
Gender
men	436/107	0.76 [0.71, 0.81]	0.76 [0.70, 0.81]	0.77 [0.72, 0.82]	0.79 [0.73, 0.84]
women	265/95	0.81 [0.76, 0.87]	0.83 [0.77, 0.88]	0.82 [0.77, 0.87]	0.86 [0.82, 0.91]a,c
Age
≤61.0 years	351/120	0.78 [0.72, 0.83]	0.79 [0.74, 0.84]	0.80 [0.75, 0.85]	0.84 [0.79, 0.88]a,b,c
>61.0 years	350/82	0.77 [0.71, 0.83]	0.76 [0.70, 0.83]	0.77 [0.71, 0.83]	0.80 [0.75, 0.86]
Race
Caucasian	323/75	0.76 [0.70, 0.82]	0.77 [0.71, 0.83]	0.79 [0.73, 0.85]	0.79 [0.74, 0.85]
African American	144/33	0.75 [0.64, 0.86]	0.76 [0.65, 0.86]	0.77 [0.68, 0.87]	0.83 [0.74, 0.91]
Hispanic	192/78	0.78 [0.71, 0.85]	0.78 [0.71, 0.85]	0.78 [0.71, 0.85]	0.82 [0.75, 0.88]a,b
Gender, age, and race adjusted	701/202	0.79 [0.75, 0.83]	0.79 [0.75, 0.83]	0.80 [0.76 to 0.83]	0.82 [0.79, 0.86]a,b,c

Bonferroni correction was applied in AUC comparison to adjust for multiple testing. ACR, first-morning void albumin:creatinine ratio; AUC, area under the ROC curve; UAE, 24-hour urinary albumin excretion; UPE, 24-hour urinary protein excretion.

^aP < 0.01 versus UAE.

^bP < 0.01 versus UPE.

^cP < 0.01 versus UAC.