Figure 3.

Nonstationary noise analysis of rClC-K1 reveals an open channel substructure. (A and C) Time dependencies of the mean current amplitudes and variances upon pulse protocols that elicit biphasic current responses for WT rClC-K1 (A) and V166E rClC-K1 (C). (B and D) Plot of variances versus mean current amplitudes from the experiments shown in panels (A) and (C). Insets show ratios of mean current variances by mean currents for three points in time referred to as positions 1 through 3 in (A) and (C) (n = 5, 6).