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. Author manuscript; available in PMC: 2010 Sep 14.
Published in final edited form as: Immunity. 2009 Jan 16;30(1):56–66. doi: 10.1016/j.immuni.2008.10.017

Figure 6. Inhibition of JNK Enhances Resistance of Bid−/− Mice to LPS plus GalN-Induced Hepatocyte Destruction.

Figure 6

(A) Bid−/−, bim−/− or wt mice were injected with JNK inhibitory peptide D-JNKI1 (30 mg/kg, i.p.) 30 min prior to treatment with 10 ng LPS plus GalN and were then monitored for survival for up to 72 h. Mice injected with LPS+GalN served as controls. P values were calculated using a time to event analysis using a log-rank test. (B) Table summarizing the long-term (followed up to 3 days) survival of wt, bid−/−, bim−/− and bim−/− bid−/− mice treated with 10 ng LPS+GalN, with or without pre-treatment with D-JNKI1. Mice that did not survive, all succumbed to the treatment within 24 h. (C) Serum levels of ALT and AST in bid−/− mice treated with 10 ng LPS plus 20 mg GalN, with or without pre-treatment with D-JNKI1 (30 mg/kg), were measured after 6 h. P-values: wt vs. bid−/−: p (ALT) = 0.09; p (AST) = 0.16. Data shown represent means +/−SD of 8–11 mice for each genotype and are derived from three independent experiments.