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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: J Gene Med. 2010 Aug;12(8):681–692. doi: 10.1002/jgm.1486

Figure 4. Tumor-selective propagation of Mdk promoter-based oncolytic adenoviruses in malignant mesothelioma cell lines.

Figure 4

(a) Human malignant mesothelioma cell lines (MESO1, MESO4, and MSTO), normal mesothelial cells (NMC), and non-malignant transformed human pleural mesothelial cells (Met5A) were infected with Ad881, Ad883, or Ad884 at an MOI of 100. Forty-eight hours after infection, cells and media were harvested to determine the viral titer in transducing units (TU) by EGFP expression using flow cytometry. (b) Virus production levels as determined above, normalized to the baseline value in NMC cells.