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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Nat Rev Neurol. 2010 Feb;6(2):67–77. doi: 10.1038/nrneurol.2009.215

Figure 2.

Figure 2

Progressive enrichment of a mild cognitive impairment cohort with future converters to Alzheimer dementia by screening for low hippocampal volume. Figures are computed from 339 patients with mild cognitive impairment from the North American Alzheimer's Disease Neuroimaging Initiative study with known conversion status at 12 month follow-up. The threshold for screening refers to the percentile of the distribution of hippocampal volume (average of right and left) in healthy elderly individuals. With an increasingly restrictive threshold, the ratio between true positives and false positives increases from 0.7 to 1.8, but the ratio of screened negatives to screened positives increases from 0.0 to 3.0.