. Author manuscript; available in PMC: 2011 Feb 1.

Published in final edited form as: J Pediatr. 2009 Oct 28;156(2):302–307. doi: 10.1016/j.jpeds.2009.09.008

Table 3.

Treatment Course

Patient	IVIG dose	Other Treatment	Medication Duration	Complications
1	2 g/kg every 4 weeks	None	IVIG every 10 weeks at 4 years	None
2	2 g/kg every 8 weeks for 3 doses; 2 doses at relapse after 2.5 years	None	Total 5 doses of IVIG	Superficial nodular calcinosis
3	2 g/kg every 4 weeks for 2 doses; 1 dose at relapse at 1 year	None	Total 3 doses of IVIG	None
4	2 g/kg every 6 weeks	Hydroxychloroquine	Total 5 doses of IVIG Discontinued hydroxychloroquine by 1 year	Headaches post IVIG
4	2 g/kg every 6 weeks	Methylphenidate hydrochloride and clonidine (for ADHD)		Headaches post IVIG
5	None	Sulfasalazine at presentation for 4 months (for arthritis)	MTX and etanercept for arthritis at 2.1 years	Tumoral calcinosis
		NSAID
		MTX started 4 months after presentation
		Etanercept added at 6 months
6	None	NSAID	Discontinued all by 8 months	None
6	None	MTX	Discontinued all by 8 months	None
7	2 g/kg every 4 weeks	MTX	Discontinued IVIG by 1 year, MTX by 2 years	Headaches post IVIG
8	2 g/kg every 2 weeks for 3 doses, then every 4 weeks	MTX	Discontinued IVIG by 18 months, MTX by 2.5 years	Headaches post IVIG
8	2 g/kg every 2 weeks for 3 doses, then every 4 weeks	Thyroxine (for hypothyroidism)	Discontinued IVIG by 18 months, MTX by 2.5 years	Headaches post IVIG

IVIG = intravenous immunoglobulin; ADHD = attention deficit hyperactivity disorder; MTX = methotrexate; NSAID = non-steroidal anti-inflammatory drug