Table 1.
Body weight and colon assessment in mice
| Group | Treatment (no. mice examined) | Body weight (g) |
Colon |
Neoplasms in colon |
|||
|---|---|---|---|---|---|---|---|
| Weight (g) | Length (cm) | W/L ratio | Incidence | Multiplicity | |||
| 1 | V. control (n = 10) | 26.46 ± 1.86 | 0.33 ± 0.05 | 10.24 ± 1.41 | 0.032 ± 0.004 | 0 | 0 |
| 2 | PMS 50 mg·kg−1 (n = 6) | 26.37 ± 2.02 | 0.31 ± 0.07 | 10.61 ± 1.27 | 0.029 ± 0.007 | 0 | 0 |
| 3 | AOM/DSS/DMSO (n = 7) | 23.97 ± 3.49 | 0.75 ± 0.22c | 8.41 ± 0.54a | 0.090 ± 0.026c | 100% | 20.86 ± 5.64c |
| 4 | AOM/DSS/PMS 25 mg·kg−1 (n = 8) | 23.18 ± 4.09a | 0.74 ± 0.23c | 8.63 ± 0.81a | 0.083 ± 0.024c | 100% | 17.75 ± 3.81c |
| 5 | AOM/DSS/PMS 50 mg·kg−1 (n = 9) | 25.48 ± 1.47 | 0.54 ± 0.15 | 8.73 ± 0.86a | 0.061 ± 0.016Ab | 100% | 13.56 ± 4.16Bc |
At the start of the experiment, there were ten mice in each group except group 2 (n = 6), and some of them died during treatment.
Data are shown as the mean ± SD.
A
P < 0.05 versus AOM/DSS/DMSO-treated group.
B
P < 0.01 versus AOM/DSS/DMSO-treated group.
a
P < 0.05 versus V. control group (vehicle control).
b
P < 0.01 versus V. control group.
c
P < 0.001 versus V. control group.
AOM, azoxymethane; DMSO, dimethyl sulphoxide; DSS, dextran sodium sulphate; PMS, 2,3′,4,4′,5′-pentamethoxy-trans-stilbene; W/L ratio (g·cm−1), colon weight per colon length.