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Pharmacological selectivity of AF-353
| Receptor | n | pIC50 ± SEMa |
|---|---|---|
| hP2X3 | 3 | 8.06 ± 0.15 |
| rP2X3 | 9 | 8.05 ± 0.03 |
| hP2X2/3 | 9 | 7.41 ± 0.08 |
| hP2X1 | 3 | <5 |
| hP2X2 | 3 | <5 |
| hP2X4 | 3 | <5 |
| rP2X5 | 3 | <5 |
| hP2X7 | 3 | <5 |
Potency estimates for all of the P2X channels were obtained from FLIPR experiments using recombinant cell lines.
