Table 3.
Haemodynamics, morphology, β-adrenoceptor density and noradrenaline concentration without and with blockade of p38 MAP kinase in sham and HF rabbits
| Sham | Sham-SB | HF3 | HF3-SB | |
|---|---|---|---|---|
| Heart rate (bpm) | 224 ± 5 | 228 ± 7 | 258 ± 15A | 264 ± 18A |
| LVEDD (mm) | 17.0 ± 0.3 | 16.8 ± 0.2 | 19.6 ± 0.5A | 18.9 ± 0.3A |
| Fractional shortening (%) | 30.0 ± 1.7 | 30.3 ± 0.6 | 10.3 ± 1.3A | 17.0 ± 1.3AB |
| Noradrenaline (ng·mL−1) | 1.33 ± 0.17 | 1.47 ± 0.27 | 3.83 ± 0.64A | 3.95 ± 1.11A |
| ß-Adrenoceptor density (fmol·mg−1) | 67 ± 5 | 69 ± 6 | 41 ± 3A | 63 ± 10AB |
| Cardiomyoycte cross-sectional area (µm2) | 242 ± 11 | 253 ± 6 | 334 ± 7A | 295 ± 4AB |
| Number of TUNEL-positive cardiomyocytes [/(1000*mm2)] | 4 ± 2 | 14 ± 5 | 50 ± 8A | 54 ± 14A |
| Phospho p38-MAPK/total p38-MAPK (relative to sham) | 1.00 ± 0.24 | 1.01 ± 0.21 | 2.34 ± 0.54A | 0.46 ± 0.24 |
| Phospho HSP27/total HSP27 (relative to sham) | 1.00 ± 0.42 | 0.49 ± 0.15 | 2.58 ± 0.60A | 1.13 ± 0.52 |
Mean ± SEM.
A
p < 0.05 versus Sham.
B
p < 0.05 versus HF3.
HF3, heart failure rabbits, 3 weeks (n = 8); HF3-SB, heart failure rabbits (3 weeks) receiving SB (n = 6); LVEDD, left ventricular end-diastolic diameter; Sham, sham-operated rabbits (n = 7); Sham-SB (n = 7), sham-operated rabbits receiving SB; TUNEL, TdT-mediated dUTP nick end labelling.