Table 1.

Plasma ibuprofen, nitrite and nitrate levels

Treatment	Ibuprofen (mg·mL−1 ± SEM)	Nitrites (µM ± SEM)	Nitrates (µM ± SEM)
Ibuprofen	8.17 ± 0.73	3.13 ± 0.13	29.91 ± 2.27
Ibuprofen plus ISDN	7.35 ± 0.85	4.16 ± 0.11*	46.16 ± 3.61*
ISDN		4.32 ± 0.10*	49.16 ± 2.37*
STD		3.27 ± 0.11	30.52 ± 3.89

^*P < 0.01 versus ibuprofen.

Plasma level of ibuprofen, nitrites and nitrates in mice treated for 1 week with standard diet (STD) or a diet containing ibuprofen, alone or together ISDN (n = 7).

ISDN, isosorbide dinitrate; STD, standard diet.