Endothelial function, as measured by flow-mediated dilation of the brachial artery, is impaired in subjects with obstructive sleep apnea (OSA), as compared with control subjects, in a subgroup of subjects younger than 50 years of age (n = 59). The box encompasses the 25%-75% quartiles, and the median is represented by the horizontal line within the box. The whiskers extend to the highest and lowest values within the higher and lower limits, respectively.