Table 2.
Observed mean (SD) polysomnography variables for sodium oxybate (SO) and placebo groups
| Night 2: Baseline |
Day 3 |
Day 4 |
Night 5: Recovery |
|||||
|---|---|---|---|---|---|---|---|---|
| Placebo | SO | Placebo | SO | Placebo | SO | Placebo | SO | |
| Total sleep time (min) | 478.6 (35.72) | 467.0 (47.51) | 171.7 (5.28) | 171.9 (8.33) | 172.4 (8.28) | 174.4 (5.23) | 550.5 (29.36) | 520.6 (55.25)‡ |
| Latency to persistent sleep (min) | 23.4 (16.81) | 32.1 (29.41) | 2.9 (3.28) | 2.2 (2.40) | 1.3 (1.13) | 2.5 (3.08) | 16.0 (17.26) | 28.2 (21.17)‡ |
| Stage 1 (min) | 65.4 (23.69) | 67.3 (20.29) | 16.2 (7.77) | 10.0 (7.97)‡‡ | 13.7 (7.53) | 11.6 (10.61) | 53.8 (18.06) | 61.8 (20.74) |
| Stage 2 (min) | 239.6 (32.62) | 239.3 (38.32) | 63.4 (16.13) | 62.5 (18.91) | 60.6 (19.05) | 66.0 (21.81) | 276.6 (37.08) | 281.8 (40.83) |
| Stage 3 (min) | 41.2 (15.75) | 37.7 (12.00) | 28.3 (13.34) | 33.5 (15.41) | 25.3 (12.31) | 34.7 (18.68)‡‡ | 51.0 (20.62) | 44.6 (17.10) |
| Stage 4 (min) | 34.1 (28.62) | 26.3 (24.86) | 32.6 (26.64) | 53.8 (26.22)‡‡ | 34.7 (25.61) | 50.5 (29.81)‡‡ | 35.0 (30.44) | 17.8 (20.24)‡ |
| SWS (min) | 75.3 (36.38) | 63.9 (26.81) | 60.9 (21.38) | 87.3 (25.76)‡‡ | 60.0 (25.07) | 85.2 (27.27)‡‡ | 86.0 (43.39) | 62.4 (29.48)‡ |
| REM (min) | 98.2 (23.65) | 96.5 (23.33) | 31.2 (14.39) | 12.2 (11.84)‡‡ | 38.0 (14.23) | 11.5 (11.23)‡‡ | 134.1 (22.58) | 114.6 (23.22)‡ |
| Wake after sleep onset (min) | 40.4 (36.05) | 43.5 (34.46) | 6.2 (3.88) | 6.5 (8.18) | 6.4 (8.10) | 3.9 (4.92) | 35.0 (29.25) | 53.8 (53.92) |
| Number of shifts to wake or Stage 1 | 52.0 (18.64) | 48.3 (15.42) | 13.0 (5.60) | 7.2 (6.29)‡‡ | 11.0 (7.70) | 7.2 (7.54) | 42.4 (14.16) | 46.5 (16.90) |
| Number of awakenings ≥ 30 sec | 33.7 (11.75) | 31.0 (10.49) | 7.1 (3.34) | 3.6 (3.21) | 6.3 (3.73) | 3.4 (3.43) | 27.8 (10.47) | 30.8 (11.84) |
| Number of awakenings ≥ 1 min | 9.7 (5.64) | 10.5 (5.66) | 2.1 (1.78) | 1.3 (1.42) | 1.5 (1.73) | 1.0 (1.22) | 6.9 (5.26) | 9.4 (6.06) |
| Latency to SWS (min) | 13.2 (4.58) | 15.0 (8.45) | 17.0 (14.97) | 20.1 (18.94) | 17.1 (12.01) | 14.4 (14.71) | 14.3 (5.23) | 37.5 (37.00) |
| REM Latency (min) | 68.3 (25.57) | 68.6 (22.49) | 45.9 (27.10) | 62.3 (63.09) | 36.3 (25.40) | 81.3 (61.52) | 62.8 (26.95) | 79.9 (47.51) |
‡
P < 0.05, sodium oxybate significantly different from placebo;
‡‡
P < 0.01, sodium oxybate significantly different from placebo