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. 2010 Aug 6;4:19. doi: 10.3389/fncir.2010.00019

Figure 4.

Figure 4

AMPARs intrinsic to the network are necessary for generation of a high frequency locomotor-like activity. (A) Effect of GYKI 52466 (20 μM) on locomotor-like activity at high frequency. VR activity was recorded in AC mode in RL2/RL5 and in DC mode in LL2/LL5. Expansions show VR activity before blockers (A1) and after full effect of GYKI 52466 (A2). (B) Statistical analysis of the effect of GYKI 52466 on moderate (left; n = 8, not significantly different) and high locomotor frequencies (right, n = 8, ***p < 0.001). (C) Plot of the difference in locomotor period (as % of change with respect to control) as function of the control period showing that the effect of GYKI 52466 was linearly proportional to the control locomotor period (R = −0.66, n = 11, p < 0.03). (D) Plot of the amplitude modulation of the L2 VR bursts (% change with respect to control) as a function of the control period showing and inverse linear correlation (R = −0.62, n = 13, p < 0.03) indicating that GYKI 52466 increased the amplitude at high locomotor frequencies but had no effect at lower locomotor frequencies.