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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Trends Endocrinol Metab. 2009 Oct 1;20(9):429–435. doi: 10.1016/j.tem.2009.06.004

Figure 3.

Figure 3

Glucocorticoid-mediated acute insulin resistance in skeletal muscle after trauma and hemorrhage (TH). Blocking the production of glucocorticoids by metyrapone or their action by RU486 inhibits the development of insulin resistance in skeletal muscle, but not liver, thereby allowing an increase in insulin-induced phosphorylation of IR, IRS-1 and Akt. Ins, insulin; IR, insulin receptor; PY, phospho-tyrosine; TH, trauma and hemorrhage; PI3K, phosphatidylinositol 3-kinase; IRSs, insulin receptor substrates; AKT, protein kinase B; GC, glucocorticoids; GR, glucocorticoid receptor.