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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Clin Pharmacol Ther. 2010 Mar 24;87(5):579–585. doi: 10.1038/clpt.2010.11

FIGURE 3.

FIGURE 3

A schematic of the PET imaging protocol used to study the healthy volunteers. The imaging protocol consisted of 5 sub-studies: 15O-water (before cyclosporine infusion, for evaluation of regional cerebral blood flow), 11C-verapamil (before cyclosporine infusion, for evaluation of regional P-gp activity at the BBB), 15O-water (during cyclosporine infusion, approximately 1 hr after onset of the cyclosporine infusion), 11C-verapamil (during cyclosporine infusion), and 11C-CO (for evaluation of tissue vascular volume).