T cell-related factors
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Interactions between T cells and antigen presenting cells |
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• Affinity of the T cell receptor-peptide-MHC interaction |
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• Co-receptor binding |
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• Co-stimulatory and checkpoint molecule interactions |
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• Adhesion molecule interactions |
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• T cell receptor expression |
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Repertoire and precursor frequency of reactive T cells as a result of positive and negative selection |
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T cell receptor down-regulation, internalization, or degradation |
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Intrinsic T cell signaling/kinase and phosphatase activity |
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Activation-induced cell death of the T cell |
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Primary vs. memory response |
Antigen-related factors
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Structure/landscape/available contact points for the T cell receptor |
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Presentation of peptide by MHC molecules/peptide-MHC affinity |
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Processing of peptides/immunodominance |
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Binding register of the peptide within the MHC molecule |
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Dose/concentration/density of peptide |
Extrinsic factors
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Adjuvant used during T cell priming |
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Regulatory T cells and other peripheral tolerance mechanisms |
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Cytokine milieu |
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Nutrient and metabolite availability |