Table III.
Stratification analysis of the association with SCCHN risk by the combined IGFBP7genotypes (− 418G>A and −702G>C)
| Variables | Cases (n=1,065) | Controls (n=1,112) | Crude OR (95% CI) Other genotypes (reference) vs GG/GG |
Adjusted OR (95% CI)a Other genotypes (reference) vs. GG/GG |
||
|---|---|---|---|---|---|---|
| Other genotypesb n (%) |
GG/GG (−418/−702) n (%) |
Other genotypesb n (%) |
GG/GG (−418/−702) n (%) |
|||
| All subjects | 686 (64.4) | 379 (35.6) | 804 (68.0) | 356 (32.0) | 1.17 (0.98–1.40) | 1.21 (1.00–1.46) |
| Age (median) | ||||||
| ≤ 57 | 361 (63.7) | 206 (36.3) | 389 (67.0) | 192 (33.0) | 1.16 (0.91–1.47) | 1.16 (0.90–1.50) |
| > 57 | 325 (65.3) | 173 (34.7) | 367 (69.1) | 164 (30.9) | 1.19 (0.92–1.55) | 1.26 (0.95–1.66) |
| Sex | ||||||
| Female | 158 (60.3) | 104 (39.7) | 179 (68.1) | 84 (31.9) | 1.40 (0.98–2.01) | 1.38 (0.94–2.03) |
| Male | 528 (65.8) | 275 (34.2) | 577 (68.0) | 272 (30.0) | 1.11 (0.90–1.36) | 1.15 (0.93–1.43) |
| Smoking Status | ||||||
| Never | 181 (60.7) | 117 (39.3) | 367 (67.5) | 177 (32.5) | 1.34 (1.00–1.80) | 1.36 (1.01–1.83) |
| Former | 247 (68.0) | 116 (32.0) | 280 (69.0) | 126 (31.0) | 1.04 (0.77–1.42) | 1.06 (0.78–1.50) |
| Current | 258 (63.9) | 146 (36.1) | 109 (67.3) | 53 (32.7) | 1.16 (0.79–1.71) | 1.11 (0.74–1.66) |
| Drinking Status | ||||||
| Never | 185 (62.5) | 111 (37.5) | 325 (66.6) | 163 (33.4) | 1.20 (0.89–1.62) | 1.21 (0.90–1.65) |
| Former | 143 (62.5) | 86 (37.5) | 120 (66.7) | 60 (33.3) | 1.20 (0.80–1.81) | 1.22 (0.80–1.87) |
| Current | 358 (66.3) | 182 (33.7) | 311 (70.1) | 133 (29.9) | 1.19 (0.91–1.56) | 1.14 (0.86–1.52) |
| Tumor Site | ||||||
| Oral Cavity | 193 (60.7) | 125 (39.3) | 756 (68.0) | 356 (32.0) | 1.38 (1.06–1.78) | 1.35 (1.02–1.77) |
| Oropharynx | 354 (65.9) | 183 (34.1) | 756 (68.0) | 356 (32.0) | 1.10 (0.88–1.37) | 1.16 (0.93–1.45) |
| Larynx/Hypopharynx | 139 (66.2) | 71 (33.8) | 756 (68.0) | 356 (32.0) | 1.09 (0.79–1.48) | 1.07 (0.75–1.52) |
a
Adjusted for age, sex, smoking and alcohol status in the logistic regression model.
b
those who carried at least one variant genotype (−418AG+AA or −702CG+CC).