Table 1. Effect of L-FABP gene ablation on weight gain in mice fed control chow ad libitum or pair-fed defined (phytol-free, phytoestrogen-free) control chow diets.a.
| Type of control chow diet | Feeding | Age (mo) | Sex | Body Weight (g) | |
|---|---|---|---|---|---|
| Rate of gain | Final Weight | ||||
| Standard rodent chow | ad libitum | < 6 mo | M, F | No change | No change |
| Standard rodent chow | ad libitum | > 6 mo | M, F | Increase | Increase |
| Defined rodent chow | pair-fed | 2.5 mo | M, F | No change | No change |
| Defined rodent chow | pair-fed | 3.5 mo | F | Increase | Increase |
| Defined rodent chow | pair-fed | 3.5 mo | M | No change | No change |
a
L-FABP null mice, age- and sex-matched (up to N10) to wild-type littermates by heterozygote/heterozygote breeding, were fed continuously on control (Rodent Diet 8604, standard low fat, 5% of energy from fat) chow from Harlan Teklad, Madison, WI. Alternately, mice were fed on this control chow for 2 mo and then pair-fed for 18 or ≥42 days on defined control (AIN-76A phytol-free, phytoestrogen-free, 5% calories from fat) chow from Research Diets, New Brunswick, NJ. Food consumption and mouse weight were determined every other day. There were no differences in food consumption in response to L-FABP gene ablation.