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. Author manuscript; available in PMC: 2011 Oct 27.
Published in final edited form as: Neuroscience. 2010 Aug 3;170(3):901–912. doi: 10.1016/j.neuroscience.2010.07.049

Fig. 1. Minocycline ameliorates the pSNL-induced enhanced activation of NMDA receptors in spinal superficial dorsal horn neurons.

Fig. 1

Shown are samples of NMDA EPSCs evoked by graded stimulation (2T stim and Max stim) in normal control rats, untreated-pSNL rats, and minocycline-pSNLrats (50 mg/kg given i.p., starting 1 h prior to nerve injury and until day 10 to 12 post-surgery). Bar graphs show the average peak amplitude, peak latency, duration, decay-time constant, and area of NMDA EPSCs obtained from normal control rats, untreated-pSNL rats, and minocycline-pSNL rats. Statistical differences of the EPSCs between untreated pSNL rats and normal control rats or minocycline pSNL rats are marked by asterisks. *P < 0.05; **P < 0.01; ***P < 0.01.