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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Psychopharmacology (Berl). 2010 Jul 28;212(2):193–203. doi: 10.1007/s00213-010-1942-4

Figure 1.

Figure 1

Data are shown for mean values (n=9) for pupil diameter (top panel) and oxygen saturation (bottom panel) after administration of morphine (left column), oxycodone (middle column) and hydrocodone (right column) as a function of time (X-axis) since drug administration in the 6 h session. Error bars omitted for clarity. Filled symbols indicate a significant difference from the corresponding placebo time point. Time course analysis revealed significant interactions of dose and time condition for pupil diameter and oxygen saturation (F189,1509 = 2.0, p < 0.0001; F189, 1507 = 1.4, p = 0.001, respectively).