Table 2.
Biodistributions in %ID/g of 99mTc-cMORF in tumor and normal organs at 3 h when administered intravenously at different dosages in mice pretargeted with 30 μg MORF-CC49 48 h earlier
Dosage (μg) | tumor size (g) | %ID/g | ID/organ | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tumor | Blood | Kidney | Liver | Spleen | Lung | Heart | Muscle | Salivary | Stomach | Small intestines | Large intestines | ||
0.97 | 0.47 | 7.89 | 3.55 | 3.33 | 1.24 | 0.71 | 1.18 | 0.80 | 0.26 | 0.76 | 0.20 | 0.50 | 2.10 |
1.48 | 0.42 | 7.74 | 2.32 | 3.38 | 0.91 | 0.63 | 0.85 | 0.56 | 0.21 | 0.54 | 0.09 | 0.40 | 2.03 |
2.01 | 0.29 | 8.66 | 2.06 | 3.44 | 0.84 | 0.49 | 0.70 | 0.43 | 0.18 | 0.50 | 0.09 | 0.35 | 2.34 |
2.20 | 0.49 | 7.08 | 1.60 | 4.05 | 0.67 | 0.47 | 0.57 | 0.33 | 0.18 | 0.45 | 0.90 | 1.35 | 2.14 |
2.36 | 0.36 | 8.40 | 1.78 | 2.94 | 0.60 | 0.35 | 0.54 | 0.37 | 0.19 | 0.33 | 0.14 | 0.22 | 2.13 |
2.60 | 0.46 | 6.48 | 1.91 | 4.49 | 0.76 | 0.44 | 0.90 | 0.37 | 0.18 | 0.53 | 0.22 | 0.51 | 3.00 |
2.79 | 0.51 | 4.92 | 1.39 | 3.54 | 0.62 | 0.44 | 0.63 | 0.37 | 0.15 | 0.28 | 0.18 | 0.95 | 2.89 |
3.03 | 0.35 | 5.96 | 1.38 | 3.51 | 0.68 | 0.38 | 0.59 | 0.31 | 0.27 | 0.35 | 0.45 | 1.29 | 2.07 |
3.19 | 0.25 | 8.22 | 1.76 | 4.56 | 0.62 | 0.38 | 0.58 | 0.32 | 0.15 | 0.34 | 0.15 | 0.46 | 2.10 |
3.41 | 0.22 | 6.10 | 1.59 | 2.89 | 0.60 | 0.29 | 0.58 | 0.31 | 0.15 | 0.32 | 0.09 | 0.32 | 1.39 |
3.61 | 0.32 | 6.30 | 1.25 | 4.25 | 0.64 | 0.31 | 0.46 | 0.22 | 0.13 | 0.37 | 0.11 | 0.61 | 2.59 |
3.88 | 0.44 | 3.90 | 1.05 | 3.00 | 0.51 | 0.28 | 0.38 | 0.22 | 0.09 | 0.28 | 0.23 | 0.29 | 2.39 |
4.05 | 0.34 | 3.93 | 0.88 | 3.77 | 0.43 | 0.19 | 0.40 | 0.22 | 0.10 | 0.25 | 0.10 | 0.27 | 1.95 |
4.47 | 0.38 | 2.91 | 0.94 | 5.24 | 0.48 | 0.27 | 0.40 | 0.20 | 0.09 | 0.24 | 0.45 | 1.28 | 1.94 |
4.83 | 0.37 | 5.64 | 0.84 | 4.19 | 0.46 | 0.34 | 0.35 | 0.19 | 0.11 | 0.19 | 1.74 | 2.16 | 2.75 |
5.16 | 0.31 | 4.49 | 1.01 | 4.59 | 0.57 | 0.33 | 0.43 | 0.28 | 0.16 | 0.32 | 0.12 | 1.15 | 2.79 |
5.66 | 0.17 | 3.45 | 1.00 | 2.69 | 0.41 | 0.26 | 0.33 | 0.20 | 0.09 | 0.23 | 1.13 | 1.55 | 2.84 |