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“Calcusyn” analysis reveals synergistic interactions between dasatinib and curcumin in variety of human colon cancer cells
| COMBINATION THERAPY | COMBINATION INDEX (CI) | ||||
|---|---|---|---|---|---|
| Das (μM) | Cur (μM) | HCT-116 (p53 wt) | HCT-116 (p53 null) | HT-29 | SW-620 |
| 0.25 | 2.5 | 0.14 | 0.25 | 0.29 | 1.09 |
| 0.5 | 5.0 | 0.17 | 0.56 | 0.51 | 0.71 |
| 1.0 | 10.0 | 0.23 | 0.53 | 0.77 | 0.86 |
| 2.0 | 20.0 | 0.32 | 0.92 | 1.16 | 0.71 |
| 4.0 | 40.0 | 0.65 | 1.2 | 1.86 | 0.45 |
CI; Combination Index < 1.0 suggests synergy
