Table 3.

Absolute and relative regional prefrontal gray matter volumes in familial high-risk (FHR) and control youth

	Absolute Volumesa		Relative Volumesb
	FHR n = 27	Controls n = 48	FHR n = 27	Controls n = 48	% Difference c	de
Ventromedial, total	4.53 ± 0.18	4.89 ± 0.12	0.38 ± .01	0.42 ± .01 d	−9.22	−0.57
Frontal Pole, total	67.19 ± 2.25	71.07 ± 1.65	5.72 ± .17	6.14 ± .12 d	−6.90	−0.50
Dorsolateral, total	58.75 ± 2.23	59.17 ± 1.15	4.96 ± .13	5.12 ± .09	−3.07	−0.25
Ventrolateral, total	16.93 ± 0.51	16.18 ± 0.40	1.44 ± 0.04	1.40 ± 0.03	3.22	0.23
Orbitofrontal, total	13.50 ± 0.54	12.57 ± 0.36	1.15 ± 0.04	1.09 ± 0.03	5.52	0.27

^aAbsolute volumes in cubic centimeters are given as mean ± standard error;

^bSignificant group × region interaction (p ≤ .04) in the repeated measures multivariate analysis of covariance predicting left and right relative prefrontal volumes in FHR vs. control subjects, adjusting for total cerebral volume and age;

^cPercent differences calculated from volumes using five decimal points for accuracy;

^dSignificant difference between groups in follow-up least square mean contrasts, p ≤ .05;

^eeffect size reported as Cohen’s d.