Table 3.
Absolute and relative regional prefrontal gray matter volumes in familial high-risk (FHR) and control youth
Absolute Volumesa | Relative Volumesb | |||||
---|---|---|---|---|---|---|
FHR n = 27 |
Controls n = 48 |
FHR n = 27 |
Controls n = 48 |
% Difference c |
de | |
Ventromedial, total | 4.53 ± 0.18 | 4.89 ± 0.12 | 0.38 ± .01 | 0.42 ± .01 d | −9.22 | −0.57 |
Frontal Pole, total | 67.19 ± 2.25 | 71.07 ± 1.65 | 5.72 ± .17 | 6.14 ± .12 d | −6.90 | −0.50 |
Dorsolateral, total | 58.75 ± 2.23 | 59.17 ± 1.15 | 4.96 ± .13 | 5.12 ± .09 | −3.07 | −0.25 |
Ventrolateral, total | 16.93 ± 0.51 | 16.18 ± 0.40 | 1.44 ± 0.04 | 1.40 ± 0.03 | 3.22 | 0.23 |
Orbitofrontal, total | 13.50 ± 0.54 | 12.57 ± 0.36 | 1.15 ± 0.04 | 1.09 ± 0.03 | 5.52 | 0.27 |
Absolute volumes in cubic centimeters are given as mean ± standard error;
Significant group × region interaction (p ≤ .04) in the repeated measures multivariate analysis of covariance predicting left and right relative prefrontal volumes in FHR vs. control subjects, adjusting for total cerebral volume and age;
Percent differences calculated from volumes using five decimal points for accuracy;
Significant difference between groups in follow-up least square mean contrasts, p ≤ .05;
effect size reported as Cohen’s d.