Table 1.

Total Area of Drusen within a 3.11-mm² Macular Study Area for Each Imaging Modality for All 12 Subjects

Eye	SD-OCT			CFP
	2D Interpolation		NWE Interpolation (mm2)	Automated (mm2)	Composite (Any 2 of 3 Graders) (mm2)	Grader 1 (mm2)	Grader 2 (mm2)	Grader 3 (mm2)
	(mm2)	%
1	0.3	9	0.2	0.5	0.5	0.6	0.5	0.5
2	0.6	19	0.6	0.8	0.8	0.9	0.9	1.0
3	0.6	19	0.6	0.6	0.6	0.4	0.6	0.7
4	0.7	22	0.7	0.6	0.6	0.8	0.6	0.7
5	0.7	23	0.7	0.9	1.0	1.0	1.0	1.0
6	0.9	29	0.9	0.7	0.8	1.0	0.7	1.1
7	1.0	32	1.0	0.7	0.9	1.4	0.9	0.7
8	1.2	39	1.2	0.9	1.1	0.9	1.2	1.3
9	1.8	58	1.9	1.6	1.4	1.6	1.2	1.4
10	2.3	75	2.4	1.9	2.0	2.0	2.0	1.9
11	2.3	73	2.4	2.3	1.8	1.9	1.7	1.9
12	3.0	95	3.0	2.7	3.1	3.1	2.2	3.1
Mean	1.3	41	1.3	1.2	1.2	1.3	1.1	1.3
SD	0.9	28	0.9	0.8	0.8	0.8	0.6	0.7

For the SD-OCT drusen map, drusen markings on a series of 100 B-scans across the macula were projected onto an SVP retinal image with interpolation of spaces between sequential scans to produce a map of drusen marking by SD- OCT (see Figs. 1, 2). The automated CFP map utilized a drusen detection algorithm to identify drusen on an enhanced, background-leveled CFP image (see Fig. 3). In addition, three retinal specialists independently graded CFPs for drusen. The composite CFP map includes all areas marked as drusen by at least two of three graders (see Fig. 2). The area of drusen expressed as a percentage of the study area is reported for one set of results (column 1, SD-OCT 2-D interpolation).